Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep.
نویسندگان
چکیده
منابع مشابه
Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep.
Protamine reversal of heparin anticoagulation in patients is occasionally associated with life-threatening acute pulmonary hypertension. In a sheep model, we evaluated the effect on this adverse cardiopulmonary reaction of modifying the type of heparin (low molecular weight heparin compared with unfractionated heparin) and the type of heparin antagonist (polybrene compared with protamine). Prot...
متن کاملThromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep.
We used competitive thromboxane A2-prostaglandin endoperoxide receptor blockade (SQ 30,741) as a probe to evaluate the role of thromboxane in ovine pulmonary vasoconstriction associated with protamine reversal of heparin anticoagulation. Control heparin-protamine reactions induced rapid release of thromboxane into arterial plasma (more than 1 ng/ml plasma), a 2.5-fold increase of pulmonary arte...
متن کاملThromboxane Receptor Blockade Prevents Pulmonary Hypertension Induced
We used competitive thromboxane A2-prostaglandin endoperoxide receptor blockade (SQ 30,741) as a probe to evaluate the role of thromboxane in ovine pulmonary vasoconstriction associated with protamine reversal of heparin anticoagulation. Control heparin-protamine reactions induced rapid release of thromboxane into arterial plasma (more than 1 ng/ml plasma), a 2.5-fold increase of pulmonary arte...
متن کاملLow Molecular Weight Heparin Overdose: A 10 Year Case Series
Background: Low molecular weight heparin (LMWH) is used for the treatment and prevention of coagulative disorders. Few patients receiving therapeutic doses of LMWH develop major hemorrhage. Currently there are few reports in the literature on acute overdose on adults. In this study, clinical profile, treatment and outcome of 21 patients who acutely overdosed enoxaparin are described. Method...
متن کاملAcute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep.
We compared alterations of pulmonary hemodynamics with the plasma concentrations of thromboxane B2, 6-keto-PGFla, and PGF20 following intravenous Escherichia coli endotoxin infusion (1 /ig/kg) in three groups of awake sheep. Group 1 served as controls. The animals in group 2 were rendered leukopenic (<1000 WBC/mm) by nitrogen mustard treatment. Group 3 received ibuprofen (12 mg/kg) one hour bef...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1990
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.82.5.1754